Recent Publications


Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3σ and YAP1.

Guo Y, Redmond CJ, Leacock KA, Brovkina MV, Ji S, Jaskula-Ranga V, Coulombe PA.

Elife. 2020 May 5;9:e53165. doi:10.7554/elife.53165.

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

Steen K, Chen D, Wang F, Majumdar R, Chen S, Kumar S, Lombard DB, Weigert R, Zieman AG, Parent CA, Coulombe PA.

Mol Biol Cell. 2020 May 15;31(11):1103-1111. doi: 10.1091/mbc.E19-10-0565.

Structure-Function Analyses of a Keratin Heterotypic Complex Identify Specific Keratin Regions Involved in Intermediate Filament Assembly.

Lee CH, Kim MS, Li S, Leahy DJ, Coulombe PA.

Structure 2020 Jan 24. 28:1-8.


Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment.

Zieman AG, Coulombe PA.

Br J Dermatol. 2020 Mar;182(3):564-573. doi: 10.1111/bjd.18033.


Pain mechanisms in hereditary palmoplantar keratodermas.

Weinberg RL, Coulombe PA, Polydefkis M, Caterina MJ.

Br J Dermatol. 2020 Mar;182(3):543-551. doi: 10.1111/bjd.17880.

Sam68 is required for the growth and survival of nonmelanoma skin cancer.

Fu K, Sun X, Xia X, Hobbs RP, Guo Y, Coulombe PA, Wan F.

Cancer Med. 2019 Oct;8(13):6106-6113. doi: 10.1002/cam4.2513.

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

Zieman AG, Poll BG, Ma J, Coulombe PA.

Hum Mol Genet. 2019 Jul 1;18(13):2255-2270.

Non-canonical processes that shape the cell migration landscape.

Majumdar R, Steen K, Coulombe PA, Parent CA.

Curr Opin Cell Biol. 2019 Apr;57:123-134. doi:10.1016/

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

Wang F, Chen S, Liu HB, Parent CA, Coulombe PA.

J Cell Biol. 2018 Nov 2. pii: jcb.201712130. doi: 10.1083/jcb.201712130.


Types I and II keratin intermediate filaments.

Jacob JT. Coulombe PA, Kwan R, Omary MB.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a018275. doi: 10.1101/cshperspect.a018275. Review.



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Epithelial Homeostasis in Health and Disease

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