Recent Publications


Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma

Zieman AG, Poll BG, Ma J, Coulombe PA.

Hum Mol Genet. 2019 Jul 1;18(13):2255-2270.


Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment

Zieman AG, Coulombe PA.

Br J Dermatol. 2019 Apr 25. doi: 10.1111/bjd. 18033.

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion

Wang F, Chen S, Liu HB, Parent CA, Coulombe PA.

J Cell Biol. 2018 Nov 2. pii: jcb.201712130. doi: 10.1083/jcb.201712130.


Types I and II keratin intermediate filaments

Jacob JT. Coulombe PA, Kwan R, Omary MB.

Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). pii: a018275. doi: 10.1101/cshperspect.a018275. Review.


The keratin 16 null phenotype is modestly impacted by genetic strain background in mice.

Zieman A, Coulombe PA.

Exp Dermatol. 2018 Jun;27(6):672-674. doi: 10.1111/exd. 13509


Sexual dimorphism in response to an NRF2 inducer in a model for Pachyonychia Congenita

Kerns ML, Hakim JMC, Zieman A, Lu RG, Coulombe PA.

J Invest Dermatol. 2018 May;138(5):1094-1100. doi: 10.1016/j.jid.2017.09.054.


Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite L, Coulombe PA, Schafer M, Dinkova-Kostova AT, Paus R, Haslam IS.

Bioessays. 2017 Aug;39(8). doi: 10.1002/bies.201700029. Epub 2017 Jul 7. Review.


The Molecular Revolution in Cutaneous Biology: keratin Genes and their Associated Disease: Diversity, Opportunities, and Challenges.

Coulombe PA.

J Invest Dermatol. 2017 May; 137(5):e67-e71. doi:10.1016/j.jid.2016.04.039. Review.


Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders.

Kerns ML, Guss L, Fahey J, Cohen B, Hakim JM, Sung S, Lu RG, Coulombe PA.

J Am Acad Dermatol. 2017 Mar 76(3):449-453. doi: 10.1016/j.jaad.2016.10.009. Epub 2016 Nov 23



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Epithelial Homeostasis in Health and Disease

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