Hot off the press! Zieman, A. and Coulombe PA. The keratin 16 null phenotype is modestly impacted by

Abby Zieman
Feb 6, 2018
1 min read

Updated: Jan 2, 2021

The lab recently reported, in Experimental Dermatology, that the severity of the palmoplantar keratoderma-like manifestations that spontaneously arise in Krt16 null mice are impacted by the genetic strain background, being less severe in the FVB relative to the C57Bl/6 strain. This is relevant because the phenotypic consequences associated with very similar missense alleles in human KRT16 vary considerably in individuals with pachyonychia congenita. Find the full story on PubMed!

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