Hot off the press! Zieman, A. and Coulombe PA. The keratin 16 null phenotype is modestly impacted by
Updated: Jan 3
The lab recently reported, in Experimental Dermatology, that the severity of the palmoplantar keratoderma-like manifestations that spontaneously arise in Krt16 null mice are impacted by the genetic strain background, being less severe in the FVB relative to the C57Bl/6 strain. This is relevant because the phenotypic consequences associated with very similar missense alleles in human KRT16 vary considerably in individuals with pachyonychia congenita. Find the full story on PubMed!